Dose Estimation for Atomic Bomb Survivor Studies: Its Evolution and Present Status

  title={Dose Estimation for Atomic Bomb Survivor Studies: Its Evolution and Present Status},
  author={Harry M Cullings and Shoichiro Fujita and Sachiyo Funamoto and Eric J Grant and George D. Kerr and Dale L Preston},
  booktitle={Radiation research},
Abstract Cullings, H. M., Fujita, S., Funamoto, S., Grant, E. J., Kerr, G. D. and Preston, D. L. Dose Estimation for Atomic Bomb Survivor Studies: Its Evolution and Present Status. Radiat. Res. 166, 219–254 (2006). In the decade after the bombings of Hiroshima and Nagasaki, several large cohorts of survivors were organized for studies of radiation health effects. The U.S. Atomic Bomb Casualty Commission (ABCC) and its U.S./Japan successor, the Radiation Effects Research Foundation (RERF), have… 
Prospects and status of the dosimetry system for atomic bomb survivor cohort study conducted at Research Institute for Radiation Biology and Medicine of Hiroshima University
The design and computational principles for the dosimetry systems in RIRBM are described and the history of the revisions, from the first version of the system, ABS93D, to the most recent version, ABS16D, are described.
Neutron relative biological effectiveness in Hiroshima and Nagasaki atomic bomb survivors: a critical review
The obtained neutron RBE, which varied with neutron dose, was confirmed to be the most adequate RBE system in terms of agreement with the cancer incidence in A-bomb survivors, using chromosome aberrations as surrogate markers.
Impact on the Japanese Atomic Bomb Survivors of Radiation Received From the Bombs
The total impact of the radiation from the bombs on the survivors is summarized from both an individual perspective (both age-specific and integrated lifetime risk, along with a measure of life expectancy that describes how the risk affects the individual given age at exposure) and a group perspective (estimated numbers of excess occurrences in the cohort).
Groups of Japanese and American scientists, supported by international collaborators, have worked for many years to ensure the accuracy of the radiation dosimetry used in studies of health effects in
Workshop Report on Atomic Bomb Dosimetry—RESIDUAL Radiation Exposure: Recent Research and Suggestions for Future Studies
Recently reported studies of residual radiation exposure in Hiroshima and Nagasaki were reviewed at a technical session at the 57th Annual Meeting of the Health Physics Society in Sacramento, California, and a one-day workshop was held to evaluate their potential use in clarifying the residual radiation exposures to the atomic-bomb survivors.
Workshop Report on Atomic Bomb Dosimetry—Review of Dose Related Factors for the Evaluation of Exposures to Residual Radiation at Hiroshima and Nagasaki
Measurements made using thermal luminescent and optically stimulated luminescence, like earlier measurements, could be expanded to detect possible radiation exposures to beta particles and to determine the extent of the various residual radiation areas at Hiroshima and Nagasaki.
Japanese Legacy Cohorts: The Life Span Study Atomic Bomb Survivor Cohort and Survivors’ Offspring
In children of survivors, no increased risks due to parental exposure to radiation have been observed for malignancies or other diseases, but investigations are continuing, as these cohorts are still relatively young, and epidemiological studies have observed increased radiation risks for malignant diseases among survivors.
Assessing the Relative Biological Effectiveness of Neutrons across Organs of Varying Depth among the Atomic Bomb Survivors.
The colon is among the deepest of organs and may not be the best choice as a single surrogate organ dose, as it may minimize the role of the neutrons, according to the traditionally modeled RBE.
Solid Cancer Incidence in Atomic Bomb Survivors: 1958–1998
There was emerging evidence from the present data that exposure as a child may increase risks of cancer of the body of the uterus, and further evidence that radiation-associated increases in cancer rates persist throughout life regardless of age at exposure.
Studies of the Mortality of Atomic Bomb Survivors, Report 14, 1950–2003: An Overview of Cancer and Noncancer Diseases
The risk of cancer mortality increased significantly for most major sites, including stomach, lung, liver, colon, breast, gallbladder, esophagus, bladder and ovary, whereas rectum, pancreas, uterus, prostate and kidney parenchyma did not have significantly increased risks.


Effect of Recent Changes in Atomic Bomb Survivor Dosimetry on Cancer Mortality Risk Estimates
Although it was anticipated that the new dosimetry system might reduce some apparent dose overestimates for Nagasaki factory workers, this did not materialize, and factory workers have significantly lower risk estimates.
Development of A-bomb survivor dosimetry
The development of the various systems of A-bomb survivor dosimetry, and the status of the current DS86 system as it is being applied in the medical follow-up studies of the A- bomb survivors and their offspring are discussed.
Recent uses of biological data for the evaluation of A-bomb radiation dosimetry.
This paper gives an overview of recent work at the Radiation Effects Research Foundation using multivariate analysis of biological data, including acute effects of radiation exposure, late effects (eg leukemia mortality) and stable chromosome aberrations, for the purpose of evaluating the extent of random error in the estimation of individual doses using DS86.
Stable Chromosome Aberrations in Atomic Bomb Survivors: Results from 25 Years of Investigation
F Frequencies of stable chromosome aberrations from more than 3,000 atomic bomb survivors were used to examine the nature of the radiation dose response and indicate that Nagasaki survivors exposed in factories, as well as people in either city who were outside with little or no shielding, had a lower dose response than those exposed in houses.
Organ dose estimates for the Japanese atomic-bomb survivors.
  • G. Kerr
  • Medicine, Physics
    Health physics
  • 1979
Investigation of Shielding of internal organs by the body has been investigated for fission-weapon gamma rays and neutrons, and ratios of mean absorbed dose in a number of organs to survivors T65D assignments of tissue kerma in air are provided.
Studies of the mortality of atomic bomb survivors. Report 12, Part I. Cancer: 1950-1990.
This continues the series of periodic general reports on cancer mortality in the cohort of A-bomb survivors followed by the Radiation Effects Research Foundation, and analysis includes an additional 10,500 survivors with recently estimated radiation doses.
Allowing for random errors in radiation dose estimates for the atomic bomb survivor data.
This report focuses on linear dose-response models, but methods for linear-quadratic models are also considered briefly, and it is found that for these error models the resulting estimates of excess cancer risk based on linear models are about 6-17% greater than estimates that make no allowance for dose estimation errors.
Mean bone marrow dose of atomic bomb survivors in Hiroshima and Nagasaki.
The ratio of the mean bone-marrow dose to in-air tissue absorbed dose for survivers in Hiroshima and Nagasaki has been calculated with the aid of the Synder mathematical phantom, using depth dose
Noncancer Disease Incidence in Atomic Bomb Survivors, 1958–1998
The results attest to the need for continued follow-up of the aging A-bomb survivors to fully elucidate the effects of radiation exposure on the occurrence of noncancer diseases.
Some effects of random dose measurement errors on analyses of atomic bomb survivor data.
  • E. Gilbert
  • Environmental Science, Physics
    Radiation research
  • 1984
It is found that the commonly applied practice of substituting 600 rad for doses exceeding this value definitely reduces bias in the presence of error and Restricting analyses to doses less than 200 rad reduces bias even more but at the price of considerable loss of power.