Dose Escalation of N , N ’ , N ’ ‘-Triethylenethiophosphoramide Combined with Pentoxifylline for Advanced Breast Cancer 1

Pentoxifylline potentiates the cytotoxicity of alkylating agents in preclinical models. In this study we sought to define the maximum tolerated dose (MTD) of N,N’,N”triethylenethiophosphoramide (thioTEPA) with pentoxifylline, and to estimate the antitumor response to this combination in previously treated breast cancer patients. Thirtyfive previously… (More)