Dose–response study of topical allyl isothiocyanate (mustard oil) as a human surrogate model of pain, hyperalgesia, and neurogenic inflammation

@article{Andersen2017DoseresponseSO,
  title={Dose–response study of topical allyl isothiocyanate (mustard oil) as a human surrogate model of pain, hyperalgesia, and neurogenic inflammation},
  author={Hjalte Holm Andersen and Silvia Lo Vecchio and Parisa Gazerani and Lars Arendt-Nielsen},
  journal={PAIN},
  year={2017},
  volume={158},
  pages={1723–1732}
}
Abstract Despite being a ubiquitous animal pain model, the natural TRPA1-agonist allyl isothiocyanate (AITC, also known as “mustard oil”) has only been sparsely investigated as a potential human surrogate model of pain, sensitization, and neurogenic inflammation. Its dose–response as an algogenic, sensitizing irritant remains to be elucidated in human skin. Three concentrations of AITC (10%, 50%, and 90%) and vehicle (paraffin) were applied for 5 minutes to 3 × 3 cm areas on the volar forearms… 
Naturally occurring glucosinolates and isothiocyanates as a weapon against chronic pain: potentials and limits
TLDR
The mechanisms underlying the ability of GLs and ITCs to modulate pain perception and, besides, to prevent the establishment of chronic pain will be described along with their pharmacokinetics and toxicological profile.
Topical treatment with a transient receptor potential ankyrin 1 (TRPA1) antagonist reduced nociception and inflammation in a thermal lesion model in rats
The time course of brief and prolonged topical 8% capsaicin-induced desensitization in healthy volunteers evaluated by quantitative sensory testing and vasomotor imaging
TLDR
Time-dependent functional recovery was almost complete 21 days after the 24 h capsaicin exposure, while recovery of neurogenic inflammatory responsiveness remained partial, and psychophysically assessed sensory deficiencies induced by the used 8% Capsaicin–ablation correspond well with a predominant effect on TRPV1+–cutaneous fibers.
Psychophysical and vasomotor evidence for interdependency of TRPA1 and TRPV1-evoked nociceptive responses in human skin: an experimental study
TLDR
It is suggested that TRPA1 nociceptive responses in human skin strongly depend on intact capsaicin-sensitive, TRPV1+ fibers.
Pathophysiological mechanisms of neuropathic pain: comparison of sensory phenotypes in patients and human surrogate pain models
TLDR
The data suggest that sorting according to human surrogate models may be useful for mechanism-based stratification of neuropathic pain patients for future clinical trials, as encouraged by the European Medicines Agency.
A Human TRPA1-Specific Pain Model
TLDR
It is shown that activation of the ion channel transient receptor potential ankyrin 1 (TRPA1) alone indeed suffices to elicit pain in humans, independent of other receptors previously found to be involved in pain generation.
Effects of allyl isothiocyanate on insulin resistance, oxidative stress status, and transcription factors in high‐fat diet/streptozotocin‐induced type 2 diabetes mellitus in rats
TLDR
AITC possesses antidiabetic, antioxidant, and anti‐inflammatory activities in HFD/STZ‐induced T2DM in rats, and may further justify the importance of AITC in phytomedicine.
Organic Isothiocyanates as H2S-donors.
TLDR
It is observed that almost all the effects of natural ITCs can be explained by the H2S release, and the development of more ITC-based synthetic H2s-donors with optimal drug-like properties and selectivity towards specific tissues/pathologies seem to represent a stimulating and indispensable prospect of future experimental activities.
Epidermal expression of human TRPM8, but not of TRPA1 ion channels, is associated with sensory responses to local skin cooling.
TLDR
The present observations demonstrating a lack of association of TRPA1 channel expression with cold sensitivity related measures reinforce doubts about involvement of this channel in cold pain in humans.
...
1
2
...

References

SHOWING 1-10 OF 124 REFERENCES
High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde.
The UVB cutaneous inflammatory pain model: a reproducibility study in healthy volunteers.
TLDR
Based on sample size calculations, it is recommended to use the erythema index to assess neurogenic inflammation, and pin-prick stimulation for primary hyperalgesia for both parallel and crossover pharmacological screening studies.
A human surrogate model of itch utilizing the TRPA1 agonist trans-cinnamaldehyde.
TLDR
Topical trans-cinnamaldehyde proved feasible as a human itch model with applicability in studying itch mechanisms or anti-pruritic drug profiling.
HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity
TLDR
Using oral administration of the selective TRPA1 antagonist HC-030031, the results demonstrated that TRPA 1 plays an important role in the mechanisms responsible for mechanical hypersensitivity observed in inflammatory and neuropathic pain models and suggested thatTRPA1 antagonism may be a suitable new approach for the development of a potent and selective therapeutic agent to treat both inflammatory and Neuropathic pain.
The Capsaicin Receptor TRPV1 Is a Crucial Mediator of the Noxious Effects of Mustard Oil
Human experimental pain models in drug development: translational pain research.
TLDR
This work has shown that biomarkers, for example, those related to the central integration of repetitive nociceptive stimuli, can predict efficacy of a given drug in neuropathic pain conditions and can act as translational research providing new possibilities for designing successful clinical trials.
Mechanism of mustard oil-induced skin inflammation in mice.
...
1
2
3
4
5
...