Dose–response relationship for exercise on severity of experimental osteoarthritis in rats: a pilot study

@article{Galois2004DoseresponseRF,
  title={Dose–response relationship for exercise on severity of experimental osteoarthritis in rats: a pilot study},
  author={Laurent Galois and St{\'e}phanie Etienne and Laurent Grossin and Astrid Watrin-Pinzano and Christel Cournil-Henrionnet and Damien Loeuille and Patrick Netter and Didier Mainard and Pierre Gillet},
  journal={Osteoarthritis and cartilage},
  year={2004},
  volume={12 10},
  pages={779-86}
}
OBJECTIVE To investigate the influence of a calibrated exercise on the progression of structural lesions in an experimental model of osteoarthritis (OA) in the rat, and to explore the effect of exercise on the level of chondrocyte caspase-dependent apoptosis and of Hsp70. METHODS The OA model was induced by anterior cruciate ligament transection (ACLT). Rats were placed in 4 experimental groups: operated (ACLT) free moving rats, and 3 exercise groups (slight, moderate and intense) subjected… CONTINUE READING

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