Dose‐dependent inhibition of theophylline metabolism by disulfiram in recovering alcoholics

@article{Loi1989DosedependentIO,
  title={Dose‐dependent inhibition of theophylline metabolism by disulfiram in recovering alcoholics},
  author={C M Loi and Julie Day and Sandra G. Jue and Ernest D Bush and Patrick G Costello and L Dewey and Robert E. Vestal},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1989},
  volume={45}
}
  • C. Loi, J. Day, +4 authors R. Vestal
  • Published 1 May 1989
  • Chemistry, Medicine
  • Clinical Pharmacology & Therapeutics
The influence of disulfiram on theophylline metabolism was studied in 20 recovering alcoholics. Ten of the patients, who were selected at random, received 250 mg of disulfiram daily. The other 10 patients received 500 mg of disulfiram daily. Two single‐dose studies of theophylline kinetics were performed— one as a baseline control and the other after 1 week of treatment with disulfiram. With disulfiram pretreatment, the plasma clearance of theophylline was decreased from 105.7 ± 10.2 (mean… 
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