Dose‐dependent effects of the 5‐HT1A receptor agonist 8‐OH‐DPAT on sleep and wakefulness in the rat

  title={Dose‐dependent effects of the 5‐HT1A receptor agonist 8‐OH‐DPAT on sleep and wakefulness in the rat},
  author={Jaime M. Monti and H{\'e}ctor Jantos},
  journal={Journal of Sleep Research},
  • J. Monti, H. Jantos
  • Published 1 September 1992
  • Biology, Psychology
  • Journal of Sleep Research
SUMMARY  Sleep and wakefulness were studied in rats following administration of a selective 5‐HT1A agonist (8‐OH‐DPAT), a non‐selective 5‐HT1A antagonist [(‐) pindolol] and a combination of 8‐OH‐DPAT and (—) pindolol. 

Effects of the selective 5‐HT1B agonist, CGS 12066B, on sleep/waking stages and EEG power spectrum in rats

The increase in waking together with a general deactivation suggest complex effects of CGS 12066B on the sleep/waking axis.

Augmentative effect of spinosin on pentobarbital‐induced loss of righting reflex in mice associated with presynaptic 5‐HT1A receptor

This study investigated whether spinosin potentiates pentobarbital‐induced loss of righting reflex (LORR) in mice via 5‐HT1A receptors via 5-HT2A receptors.

Depletion of brain serotonin by 5,7-DHT: effects on the 8-OH-DPAT-induced changes of sleep and waking in the rat

Findings tend to indicate that increased SWS after low doses of 8-OH-DPAT depends upon the activation of inhibitory somatodendritic 5-HT1A receptors, while increased W after higher doses of the compound is related to stimulation of postsynaptic receptors.

MDMA self-administration fails to alter the behavioral response to 5-HT1A and 5-HT1B agonists

Cognitive and behavioral deficits produced by repeated exposure to MDMA self-administration are not likely due to alterations in 5-HT1A or 5- HT1B receptor mechanisms.

Involvement of the 5-HT1A and the 5-HT1B receptor in the regulation of sleep and waking

Overall, most studies support the possibility that stimulation of postsynaptic 5-HT1A receptors, e.g., via systemic administration of a high dose of agonists increases wakefulness and decreases sleep and the mechanism by which 5- HT1B receptors affect state modulation remain elusive.



Effects of 8-OH-DPAT on motor activity in the rat

Electrophysiological assessment of putative antagonists of 5-hydroxytryptamine receptors: a single-cell study in the rat dorsal raphe nucleus.

Results indicate that, among the five putative 5-HT receptor antagonists tested, only spiperone can antagonize the suppressant effect of 5-hydroxytryptamine1A (5-HT1A) receptor agonists on the firing of dorsal raphe 5- HT neurons.

Electrophysiology of Central Serotonin Receptor Subtypes

This conclusion derives from the finding that the neuroleptic agent spiperone labels 5-HT binding sites in the frontal cortex that exhibit features distinct from those sites labeled by [3H]5-HT itself (Peroutka and Snyder, 1979).

The Biochemical Basis of Neuropharmacology

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  • Medicine
    The Yale Journal of Biology and Medicine
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The monograph tells us that EP is the principle hormone which regulates erythropoiesis, and how it acts by causing a committed but undifferentiated cell to differentiate into an erythroblast, and may also have a role in causing maturation of ERYthroblasts.

5-Hydroxytryptamine1A receptors and behavioral responses.

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  • Biology, Psychology
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  • 1990
The special role of behavioral studies in attempting to understand the substrates for the psychotherapeutic actions of 5-hydroxytryptamine1A (5-HT1A)-selective agents, such as buspirone and other

5-HT2 receptors could be primarily involved in the regulation of slow-wave sleep in the rat.