Dose‐dependent Induction of Liver and Thyroid Neoplastic Lesions by Short‐term Administration of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline Combined with Partial Hepatectomy Followed by Phenobarbital or Low Dose 3′‐Methyl‐4‐dimethylaminoazobenzene Promotion

Abstract

Dietary administration of 0.1, 0.05, or 0.025% 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) for two weeks combined with partial hepatectomy at the end of the first week and followed by long-term treatment with phenobarbital (PB) or 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) from week 3 to week 86 resulted in dose-dependent development of liver and… (More)

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