Dose‐Related Effects of Estazolam on Sleep of Patients with Insomnia

  title={Dose‐Related Effects of Estazolam on Sleep of Patients with Insomnia},
  author={Timothy Roehrs and Frank J. Zorick and Norman John Lord and Gail Koshorek and Thomas Roth},
  journal={Journal of Clinical Psychopharmacology},
The dose range of estazolam for hypnotic effects was studied in seven men and eight women (mean age 30.3 ± 8.6 years) who complained of insomnia and had polysomnographic evidence of disturbed sleep. Patients slept in the laboratory and were monitored using standard polysomnographic techniques. Four consecutive nights in the laboratory with placebo, which served as baseline and screening nights, were followed by five 2-night drug administration periods separated by 5-day drug washout periods… 
The dose effects of zopiclone
In general, hypnotic effects leveled off at the 5 mg dose while sleep stage effects increased with higher doses, and sleep staging effects changed in a dose‐dependent fashion with the 7·5 mg and higher doses significantly different from both placebo and the 2·5mg dose.
Hypnotic Efficacy of Estazolam Compared with Flurazepam in Outpatients with Insomnia
Estazolam 2 mg was found to be as effective a hypnotic as flurazepam 30 mg and is also effective in the treatment of outpatients with insomnia, but to a lesser degree.
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Zaleplon appeared to have hypnotic properties consistent with its pharmacokinetic profile, and a low likelihood of undesired effects in a double-blind, placebo-controlled design.
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This study demonstrates short-term efficacy of zaleplon, particularly at the 5 and 10mg doses, in older patients with insomnia in a Randomised, double-blind, placebo-controlled, Latin-square design.
Efficacy of estazolam. The United States clinical experience.
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Estazolam and flurazepam effectively, and comparably, relieved insomnia when administered for 7 nights in adult patients complaining of insomnia.
Pharmacological Treatment of Insomnia
Benzodiazepines remain the recommended hypnotic agents, although newer, non-benzodiazepine agents may also be utilised and use of alcohol for its sedative properties, and over-the-counter preparations, are not recommended for the treatment of insomnia.
Safety of estazolam. The United States clinical experience.
The assessment and management of insomnia: an update
There are an array of interventions which have been demonstrated to have therapeutic effects in insomnia in trials with the above features, and whose risk/benefit profiles have been well characterized, and these interventions can form the basis for systematic, evidence‐based treatment of insomnia in clinical practice.
Sedatives and Hypnotics
This chapter will discuss the uses of hypnotics and sedatives for the treatment of insomnia and outline appropriate management strategies for effective treatment outcomes.