Dosage sensitivity and the evolution of gene families in yeast

@article{Papp2003DosageSA,
  title={Dosage sensitivity and the evolution of gene families in yeast},
  author={Bal{\'a}zs Papp and Csaba P{\'a}l and Laurence D. Hurst},
  journal={Nature},
  year={2003},
  volume={424},
  pages={194-197}
}
According to what we term the balance hypothesis, an imbalance in the concentration of the subcomponents of a protein–protein complex can be deleterious. If so, there are two consequences: first, both underexpression and overexpression of protein complex subunits should lower fitness, and second, the accuracy of transcriptional co-regulation of subunits should reflect the deleterious consequences of imbalance. Here we show that all these predictions are upheld in yeast (Saccharomyces cerevisiae… 
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