Dosage effects of curcumin on cell death types in a human osteoblast cell line.

  title={Dosage effects of curcumin on cell death types in a human osteoblast cell line.},
  author={Wen-Hsiung Chan and Hsiao-Yun Wu and Walter H. Chang},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  volume={44 8},
Curcumin, the yellow pigment of Curcuma longa, is known to have antioxidant and anti-inflammatory properties, as well as their ability to either induce or prevent cell apoptosis. However, the precise molecular mechanisms of these effects are unknown. Here, we demonstrate that curcumin can induce apoptotic changes, including JNK activation, caspase-3 activation, and cleavage of PARP and PAK2, at treatment concentrations lower than 25 microM in human osteoblast cells. In contrast, treatment with… CONTINUE READING


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