Dosage-dependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome.

@article{Amano2004DosagedependentOO,
  title={Dosage-dependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome.},
  author={Kenji Amano and Haruhiko Sago and Chiharu Uchikawa and Taishi Suzuki and Svetlana E Kotliarova and Nobuyuki Nukina and Charles J. Epstein and Kazuhiro Yamakawa},
  journal={Human molecular genetics},
  year={2004},
  volume={13 13},
  pages={1333-40}
}
Down syndrome (DS) is the most common chromosomally caused form of mental retardation and is caused by trisomy of chromosome 21. The over-expression of genes located on the trisomic region has been assumed to be responsible for the phenotypic abnormalities of DS, but this hypothesis has not been confirmed fully and the very existence of gene dosage effects has been called into question. We have therefore investigated global gene expression profiles in Ts1Cje, a mouse model for DS that displays… CONTINUE READING
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