Dosage-dependent hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia formation as an appendicular program.

@article{Miyagawa2009DosagedependentHS,
  title={Dosage-dependent hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia formation as an appendicular program.},
  author={Shinichi Miyagawa and Anne Moon and Ryuma Haraguchi and Chie Inoue and Masayo Harada and Chiaki Nakahara and Kentaro Suzuki and Daisuke Matsumaru and Takehito Kaneko and Isao Matsuo and Lei Yang and Makoto Mark Taketo and Taisen Iguchi and Sylvia M. Evans and Gen Yamada},
  journal={Development},
  year={2009},
  volume={136 23},
  pages={3969-78}
}
Embryonic appendicular structures, such as the limb buds and the developing external genitalia, are suitable models with which to analyze the reciprocal interactions of growth factors in the regulation of outgrowth. Although several studies have evaluated the individual functions of different growth factors in appendicular growth, the coordinated function and integration of input from multiple signaling cascades is poorly understood. We demonstrate that a novel signaling cascade governs… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 44 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 84 references

Similar Papers

Loading similar papers…