Dosage Compensation by Gene-Copy Silencing in a Triploid Hybrid Fish

@article{Pala2008DosageCB,
  title={Dosage Compensation by Gene-Copy Silencing in a Triploid Hybrid Fish},
  author={Irene Pala and Maria Manuela Coelho and Manfred Schartl},
  journal={Current Biology},
  year={2008},
  volume={18},
  pages={1344-1348}
}
In mammals, the increase in gene dosage, in the form of polyploidy or involving chromosomal fragments, has deleterious effects [1]. Regulation of appropriate gene product amounts has to be warranted by complex dosage-compensation mechanisms. Lower vertebrates, on the other hand, cope very well with ploidy increase [2-4], implying either effective compensation or a lack of necessity for such mechanisms. Unfortunately, nothing is known about the genetic and molecular mechanisms underlying this… CONTINUE READING

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