Dorsoventral Axis Formation in the Drosophila Embryo—Shaping and Transducing a Morphogen Gradient

  title={Dorsoventral Axis Formation in the Drosophila Embryo—Shaping and Transducing a Morphogen Gradient},
  author={Bernard Moussian and Siegfried Roth},
  journal={Current Biology},

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Temporal dynamics, spatial range, and transcriptional interpretation of the Dorsal morphogen gradient.

Graded dorsal and differential gene regulation in the Drosophila embryo.

How Dorsal controls differential gene expression is focused on and how recent studies have expanded the understanding of Drosophila embryonic development from the cis-regulatory level to that controlling morphogenesis of the embryo.

Generation and timing of graded responses to morphogen gradients

The role of the Dorsal protein nuclear gradient along the dorso-ventral axis in defining the graded pattern of actomyosin constriction that initiates gastrulation in early Drosophila embryos is explored.

The Presence of Nuclear Cactus in the Early Drosophila Embryo May Extend the Dynamic Range of the Dorsal Gradient

This model explains the dynamic behavior of the Dorsal gradient at lateral and dorsal positions of the embryo, the ability ofDorsal to regulate gene expression across the entire dorsal-ventral axis, and the robustness of gene expression to stochastic effects.

Dynamics of the Dorsal morphogen gradient

A mathematical model of the Dl gradient is developed and predicted that it is dynamic and can be described as a concentration profile with increasing amplitude and constant shape, different from those of the Bicoid and MAPK phosphorylation gradients, which pattern the anterior and terminal regions of the embryo.

Maternal control of the Drosophila dorsal–ventral body axis

Classic studies are reviewed and the details of more recent work that has advanced the understanding of the complex pathway that establishes Drosophila embryo DV polarity are integrated.



The origin of dorsoventral polarity in Drosophila.

  • S. Roth
  • Biology
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2003
In Drosophila dorsoventral (DV) polarity arises during oogenesis when the oocyte nucleus moves from a central posterior to an asymmetrical anterior position and establishes orthogonality between the anteroposterior and the DV axes.

Spätzle regulates the shape of the Dorsal gradient in the Drosophila embryo.

Dorsal-ventral polarity of the Drosophila embryo is established by a nuclear gradient of Dorsal protein, generated by successive gurken-Egfr and spätzle-Toll signaling, which is addressed by a model that invokes action of a diffusible inhibitor.

Dorsal gradient networks in the Drosophila embryo.

Dorsal patterning thresholds represent the culmination of one of the most complete gene regulation network known in development, which begins with the asymmetric positioning of the oocyte nucleus within the egg chamber and leads to the localized activation of the Toll-DORSal signaling pathway in ventral regions of the early embryo.

Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo.

The dorsal-ventral pattern of the Drosophila embryo is established by three sequential signaling pathways, each of which uses a distinct strategy to achieve spatial localization of signaling activity.

Threshold responses to the dorsal regulatory gradient and the subdivision of primary tissue territories in the Drosophila embryo.

Mechanisms of Gurken-dependent pipe regulation and the robustness of dorsoventral patterning in Drosophila.

Findings support the view that the pipe domain is directly delimited by a long-range Gurken gradient and indicates that potent inhibitory processes prevent pipe dependent Toll activation at the dorsal side of the egg.

Regulation of Easter activity is required for shaping the Dorsal gradient in the Drosophila embryo

The experiments suggest that the eaD mutations interfere with inactivation of catalytic Easter, and imply that this negative regulation is essential for generating the wild-type shape of the Dorsal gradient.

Robustness of the BMP morphogen gradient in Drosophila embryonic patterning

It is found that the BMP activation gradient itself is robust to changes in gene dosage, and it is shown experimentally that Dpp is widely diffusible in the presence of Sog but tightly localized in its absence, thus validating a central prediction of the theoretical study.