Dorsoventral Axis Formation in the Drosophila Embryo—Shaping and Transducing a Morphogen Gradient

@article{Moussian2005DorsoventralAF,
  title={Dorsoventral Axis Formation in the Drosophila Embryo—Shaping and Transducing a Morphogen Gradient},
  author={Bernard Moussian and Siegfried Roth},
  journal={Current Biology},
  year={2005},
  volume={15},
  pages={R887-R899}
}
The graded nuclear location of the transcription factor Dorsal along the dorsoventral axis of the early Drosophila embryo provides positional information for the determination of different cell fates. Nuclear uptake of Dorsal depends on a complex signalling pathway comprising two parts: an extracellular proteolytic cascade transmits the dorsoventral polarity of the egg chamber to the early embryo and generates a gradient of active Spätzle protein, the ligand of the receptor Toll; an… Expand
Temporal dynamics, spatial range, and transcriptional interpretation of the Dorsal morphogen gradient.
TLDR
Combinatorial effects of uniform and graded factors play an important role in the transcriptional and signaling cascades initiated by Dorsal and may explain differential positioning of gene expression borders by other morphogen gradients. Expand
Graded dorsal and differential gene regulation in the Drosophila embryo.
TLDR
How Dorsal controls differential gene expression is focused on and how recent studies have expanded the understanding of Drosophila embryonic development from the cis-regulatory level to that controlling morphogenesis of the embryo. Expand
Generation and timing of graded responses to morphogen gradients
TLDR
The role of the Dorsal protein nuclear gradient along the dorso-ventral axis in defining the graded pattern of actomyosin constriction that initiates gastrulation in early Drosophila embryos is explored. Expand
Stepwise Progression of Embryonic Patterning.
TLDR
An overview of DV axis patterning is provided, focusing on new insights identified through quantitative analysis of temporal changes in Dorsal target gene expression from one nuclear cycle to the next ('steps'). Expand
The Presence of Nuclear Cactus in the Early Drosophila Embryo May Extend the Dynamic Range of the Dorsal Gradient
TLDR
This model explains the dynamic behavior of the Dorsal gradient at lateral and dorsal positions of the embryo, the ability ofDorsal to regulate gene expression across the entire dorsal-ventral axis, and the robustness of gene expression to stochastic effects. Expand
Signaling Cascades, Gradients, and Gene Networks in Dorsal/Ventral Patterning
TLDR
Loss and gain-of-function genetic analysis carried out in flies, frogs, and fish demonstrate that this role of the Dpp/Sog morphogen system in patterning the DV axis is conserved in both invertebrates and vertebrates. Expand
Dynamics of the Dorsal morphogen gradient
TLDR
A mathematical model of the Dl gradient is developed and predicted that it is dynamic and can be described as a concentration profile with increasing amplitude and constant shape, different from those of the Bicoid and MAPK phosphorylation gradients, which pattern the anterior and terminal regions of the embryo. Expand
Maternal control of the Drosophila dorsal–ventral body axis
  • D. Stein, L. Stevens
  • Biology, Medicine
  • Wiley interdisciplinary reviews. Developmental biology
  • 2014
TLDR
Classic studies are reviewed and the details of more recent work that has advanced the understanding of the complex pathway that establishes Drosophila embryo DV polarity are integrated. Expand
Dorsoventral Polarity of the Nasonia Embryo Primarily Relies on a BMP Gradient Formed without Input from Toll
TLDR
It is found that wasp Toll has a very limited ventral role, whereas BMP is required for almost all DVPolarity of the embryo, and these two signaling systems act independently of each other to generate DV polarity. Expand
Formation, interpretation, and regulation of the Drosophila Dorsal/NF-κB gradient.
TLDR
The mechanisms behind the initiation of the Dorsal gradient and its regulation of target genes are described, and a discussion of quantitative and computational studies ofThe Dl gradient system, including regulation of theDl gradient is discussed. Expand
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