Dorsolateral prefrontal contributions to human working memory

@article{Barbey2013DorsolateralPC,
  title={Dorsolateral prefrontal contributions to human working memory},
  author={A. Barbey and M. Koenigs and J. Grafman},
  journal={Cortex},
  year={2013},
  volume={49},
  pages={1195-1205}
}
Although neuroscience has made remarkable progress in understanding the involvement of prefrontal cortex (PFC) in human memory, the necessity of dorsolateral PFC (dlPFC) for key competencies of working memory remains largely unexplored. We therefore studied human brain lesion patients to determine whether dlPFC is necessary for working memory function, administering subtests of the Wechsler Memory Scale, the Wechsler Adult Intelligence Scale, and the N-Back Task to three participant groups… Expand
Dorsolateral prefrontal contributions to human intelligence
TLDR
The observed findings support a central role for the dlPFC in global aspects of general intelligence and make specific recommendations for the interpretation and application of the WAIS and D-KEFS to the study of high-level cognition in health and disease. Expand
Causal evidence supporting functional dissociation of verbal and spatial working memory in the human dorsolateral prefrontal cortex
TLDR
These findings provide human evidence for domain‐specific contributions of the dlPFC to working memory and reinforce the potential of rTMS to ameliorate cognition. Expand
Hippocampal–Dorsolateral Prefrontal Coupling as a Species-Conserved Cognitive Mechanism: A Human Translational Imaging Study
TLDR
HC–DLPFC coupling may represent a systems-level mechanism specific to spatial WM that is conserved across species, suggesting its utility for modeling cognitive dysfunction in translational neuroscience. Expand
Independent Contributions of Dorsolateral Prefrontal Structure and Function to Working Memory in Healthy Older Adults.
TLDR
BOLD signal and surface area may independently contribute to working memory performance in healthy older adults, according to Binary logistic regressions adjusting for age, sex, education, and scanner type. Expand
Improved Working Memory Performance through Self-Regulation of Dorsal Lateral Prefrontal Cortex Activation Using Real-Time fMRI
TLDR
Preliminary evidence that working memory performance can be improved through learned regulation of activation in associated brain regions using rtfMRI is provided. Expand
Context-dependency in the Cognitive Bias Task and Resting-state Functional Connectivity of the Dorsolateral Prefrontal Cortex
TLDR
The findings suggest that CD and CI are associated with different patterns of DLPFC FC, probably involved in the inhibition of the CD response and switching from processing of incoming perceptual information to creation of original response strategies. Expand
Brain Activation in the Prefrontal Cortex during Motor and Cognitive Tasks in Adults
The prefrontal cortex (PFC) plays an important role in cognitive function, involved in Executive Functions (EFs) such as planning, working memory, and inhibition. Activation in the PFC also occursExpand
Layer-dependent activity in human prefrontal cortex during working memory
TLDR
High-resolution functional MRI is used to interrogate the layer specificity of neural activity during different epochs of a working memory task in dlPFC to demonstrate that layer-specific fMRI can be used in higher-order brain regions to non-invasively map cognitive information processing along cortical circuitry in humans. Expand
Cerebellum and cognition: Does the rodent cerebellum participate in cognitive functions?
TLDR
There is a solid body ofSupport for engagement of the rodent cerebellum in tests of cognitive flexibility and spatial navigation, and some support for engagement in working memory and certain types of discrimination learning. Expand
Preservation of Interference Effects in Working Memory After Orbitofrontal Damage
TLDR
Although the groups had different electrophysiological responses, the maintenance of letters in WM, the evaluation of the context of the probe, and the decision to accept or reject a probed letter were preserved in OFC patients, suggesting that neural reorganization may contribute to intact recency judgment and response after OFC damage. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 73 REFERENCES
Orbitofrontal contributions to human working memory.
TLDR
The findings elucidate a central component of the neural architecture of working memory, providing key neuropsychological evidence for the necessity of the orbitofrontal cortex in executive control functions underlying the joint maintenance, manipulation, and monitoring of information in working memory. Expand
Dorsolateral prefrontal contributions to human intelligence
TLDR
The observed findings support a central role for the dlPFC in global aspects of general intelligence and make specific recommendations for the interpretation and application of the WAIS and D-KEFS to the study of high-level cognition in health and disease. Expand
Superior Parietal Cortex Is Critical for the Manipulation of Information in Working Memory
In recent years, theoretical perspectives on posterior parietal function have evolved beyond the traditional visuospatial processing models to include more diverse cognitive operations, such asExpand
Is the Prefrontal Cortex Necessary for Delay Task Performance? Evidence from Lesion and fMRI Data
TLDR
The combined imaging and behavioral data suggest that working memory rehearsal/maintenance processes may depend on both hemispheres, which may have implications for recovery of function and development of rehabilitation therapies after frontal injury. Expand
Repetitive Transcranial Magnetic Stimulation Dissociates Working Memory Manipulation from Retention Functions in the Prefrontal, but not Posterior Parietal, Cortex
TLDR
Results in the PFC are consistent with the view that this region contributes more importantly to the control of information in working memory than to its STR, and in the SPL, they illustrate the importance of supplementing the fundamentally correlational data from neuroimaging with a disruptive method, which affords stronger inference about structure-function relations. Expand
Temporal dynamics of brain activation during a working memory task
TLDR
Functional magnetic resonance imaging is used to examine brain activation in human subjects during performance of a working memory task and to show that prefrontal cortex along with parietal cortex appears to play a role in active maintenance. Expand
The dependence of span and delayed-response performance on prefrontal cortex
TLDR
An analysis of reports of performance on tests of working memory of patients with lesions of the dorsolateral prefrontal cortex, focusing on published reports in the literature of simple span and delayed-response tasks, found that none of the eleven studies of forward verbal and spatial span in patients with prefrontal cortical lesions demonstrated a statistically significant deficit relative to normal controls. Expand
Dissociable Roles of Mid-Dorsolateral Prefrontal and Anterior Inferotemporal Cortex in Visual Working Memory
  • M. Petrides
  • Psychology, Medicine
  • The Journal of Neuroscience
  • 2000
TLDR
A demonstration of a double dissociation between the effects of these two lesions provides strong evidence that the role of the mid-dorsolateral prefrontal cortex in visual working memory does not lie in the maintenance of information per se, but rather in the executive process of monitoring this information. Expand
Association of Storage and Processing Functions in the Dorsolateral Prefrontal Cortex of the Nonhuman Primate
TLDR
A functional segregation within the dorsolateral prefrontal cortex for WM is supported, in the nonhuman primate, an areal dissociation based on domain rather than on processing demand. Expand
Temporal isolation of the neural correlates of spatial mnemonic processing with fMRI.
TLDR
Functional changes attributable to the memory requiring phase of a spatial working memory task were temporally discriminated from those attributable to other behavioral subcomponents within trials using an experimental design argued to obviate these assumptions, as well as permit a joint test of their validity. Expand
...
1
2
3
4
5
...