Dorsolateral funiculus lesioning of the mouse cervical spinal cord at C4 but not at C6 results in sustained forelimb motor deficits.

@article{Hilton2013DorsolateralFL,
  title={Dorsolateral funiculus lesioning of the mouse cervical spinal cord at C4 but not at C6 results in sustained forelimb motor deficits.},
  author={Brett J Hilton and Peggy Assinck and Greg J Duncan and Daniel Lu and Stephanie W Lo and Wolfram Tetzlaff},
  journal={Journal of neurotrauma},
  year={2013},
  volume={30 12},
  pages={1070-83}
}
Although upper extremity functional recovery is a high priority for spinal cord injured patients with cervical injuries, few injury models have been developed in mice with sustained deficits in forelimb motor function. Here, we characterize a dorsolateral funiculus (DLF) crush model in mice, which ablates the rubrospinal tract (RST) unilaterally and thus allows correlation of motor recovery to axonal regeneration in the assessment of molecular regeneration targets. We conducted unilateral DLF… CONTINUE READING
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