Dorsolateral caudate nucleus differentiates cocaine from natural reward-associated contextual cues.

@article{Liu2013DorsolateralCN,
  title={Dorsolateral caudate nucleus differentiates cocaine from natural reward-associated contextual cues.},
  author={Hua-Shan Liu and Svetlana I. Chefer and Hanbing Lu and Karine Guillem and William Rea and Pradeep K. Kurup and Yihong Yang and Laura L. Peoples and Elliot A. Stein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 10},
  pages={4093-8}
}
Chronic drug administration induces neuroplastic changes within brain circuits regulating cognitive control and/or emotions. Following repeated pairings between drug intake and environmental cues, increased sensitivity to or salience of these contextual cues provoke conscious or unconscious craving and enhance susceptibility to relapse. To explore brain circuits participating in such experience-induced plasticity, we combined functional MRI with a preclinical drug vs. food self-administration… CONTINUE READING
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