Dorsolateral Prefrontal Cortex N-Acetylaspartate/Total Creatine (NAA/tCr) Loss in Male Recreational Cannabis Users

  title={Dorsolateral Prefrontal Cortex N-Acetylaspartate/Total Creatine (NAA/tCr) Loss in Male Recreational Cannabis Users},
  author={Derik Hermann and Alexander Sartorius and Helga Welzel and Sigrid Walter and Gisela Skopp and Gabriele Ende and Karl F. Mann},
  journal={Biological Psychiatry},

Frontal Metabolite Concentration Deficits in Opiate Dependence Relate to Substance Use, Cognition, and Self-Regulation

The frontal lobe metabolite abnormalities in OD and their neuropsychological correlates may play a role in treatment outcome and could be explored as specific targets for improved OD treatment.

Lower Left Thalamic Myo-Inositol Levels Associated with Greater Cognitive Impulsivity in Marijuana-Dependent Young Men: Preliminary Spectroscopic Evidence at 4T

The current findings indicate that reduced mI levels are regionally specific to the lThal in MRJ users and suggest that mI and the l thal uniquely contribute to elevated impulsivity.

Evidence That Cannabis Exposure, Abuse, and Dependence Are Related to Glutamate Metabolism and Glial Function in the Anterior Cingulate Cortex: A 1H-Magnetic Resonance Spectroscopy Study

Evidence linking problematic drug use behaviors with glial function as measured with myo-inositol and recent chronic cannabis exposure to alterations in glutamate metabolism is provided, providing novel directions for the interrogation of the impact of cannabis use on brain neurochemistry.

Decreased frontal N-acetylaspartate levels in adolescents concurrently using both methamphetamine and marijuana

An Investigation of Neurochemical Changes in Chronic Cannabis Users

It is suggested that dose may significantly influence the observance of CB effects and that those effects may be modulated by sex with the effect of monthly use (dose) being stronger in males than in females.

Glutamate, N-acetyl aspartate and psychotic symptoms in chronic ketamine users

The finding of lower thalamic NAA/Cr in chronic ketamine users may be secondary to the effects of ketamine use compared to other drugs of abuse and resembles previous reports in individuals at genetic or clinical risk of schizophrenia.

Adolescent‐onset heavy cannabis use associated with significantly reduced glial but not neuronal markers and glutamate levels in the hippocampus

Altered myoinositol levels may be a marker of glia dysfunction and is consistent with experimental preclinical evidence that cannabinoid‐induced glial dysfunction may underlie cannabinoid-induced memory impairments in CUs.

MR spectroscopy in opiate maintenance therapy: association of glutamate with the number of previous withdrawals in the anterior cingulate cortex

Positive correlation of glutamate and previous withdrawals and increasing Glx with age in contrast to an age‐dependent Glx decrease in controls indicate a destabilization of the glutamate system in opiate‐dependent patients and support the glutamate hypothesis of addiction.



Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorder.

The results support other evidence that neuronal pathology in the dorsolateral prefrontal cortex accounts for a proportion of working memory deficits already present at illness outset.

Changes in putamen N-acetylaspartate and choline ratios in untreated and levodopa-treated Parkinson's disease: A proton magnetic resonance spectroscopy study

It is suggested that NAA/Cho ratios may be affected by L-dopa therapy and this may provide a reversible marker of neuronal dysfunction in the striatum.

Lower concentration of thalamic n-acetylaspartate in patients with schizophrenia: a replication study.

There is strong evidence for neuronal dysfunction or loss in the mediodorsal region of the thalamus in patients with schizophrenia.

Effects of Smoking Marijuana on Brain Perfusion and Cognition