Dorsally derived netrin 1 provides an inhibitory cue and elaborates the 'waiting period' for primary sensory axons in the developing spinal cord.

@article{Watanabe2006DorsallyDN,
  title={Dorsally derived netrin 1 provides an inhibitory cue and elaborates the 'waiting period' for primary sensory axons in the developing spinal cord.},
  author={Keisuke Watanabe and Nobuaki Tamamaki and Takahiro Furuta and Susan L Ackerman and Kazuhiro Ikenaka and Katsuhiko Ono},
  journal={Development},
  year={2006},
  volume={133 7},
  pages={1379-87}
}
Dorsal root ganglion (DRG) neurons extend axons to specific targets in the gray matter of the spinal cord. During development, DRG axons grow into the dorsolateral margin of the spinal cord and projection into the dorsal mantle layer occurs after a ;waiting period' of a few days. Netrin 1 is a long-range diffusible factor expressed in the ventral midline of the developing neural tube, and has chemoattractive and chemorepulsive effects on growing axons. Netrin 1 is also expressed in the dorsal… CONTINUE READING