Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene.

@article{Kasai1992DorsalventralPI,
  title={Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene.},
  author={Yasushi Kasai and John R. Nambu and Paul M. Lieberman and Stephen T. Crews},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 8},
  pages={
          3414-8
        }
}
The Drosophila snail gene is required for proper mesodermal development. Genetic studies suggest that it functions by repressing adjacent ectodermal gene expression including that of the single-minded (sim) gene. The snail gene encodes a protein with a zinc-finger motif, and here we report that the snail gene product is a sequence-specific DNA binding protein. The snail protein recognizes a 14-base-pair consensus sequence that is found nine times in a 2.8-kilobase sim regulatory region. These… CONTINUE READING

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