Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice.

@article{Iwasato2004DorsalTE,
  title={Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice.},
  author={Takuji Iwasato and Ryochi Nomura and Reiko Ando and Toshio Ikeda and Mika Tanaka and Shigeyoshi Itohara},
  journal={Genesis},
  year={2004},
  volume={38 3},
  pages={130-8}
}
The ability to restrict gene expression or disruption to specific regions of the brain would enhance understanding of the molecular basis for brain development and function. For this purpose, brain region-restricted promoters are essential. Here we report the isolation of a DNA fragment containing the Emx1 gene promoter, which is responsible for dorsal telencephalon-specific expression. The Cre recombinase gene was inserted into a mouse PAC (P1-derived artificial chromosome) Emx1-locus clone… CONTINUE READING

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