Dorsal root potentials and dorsal root reflexes: a double-edged sword

@article{Willis1999DorsalRP,
  title={Dorsal root potentials and dorsal root reflexes: a double-edged sword},
  author={William D. Willis},
  journal={Experimental Brain Research},
  year={1999},
  volume={124},
  pages={395-421}
}
  • W. Willis
  • Published 1 February 1999
  • Chemistry, Medicine
  • Experimental Brain Research
 The nature of dorsal root reflexes (DRRs) and their possible role in peripheral inflammation and the consequent hyperalgesia are reviewed. The history of DRRs and the relationship of DRRs to primary afferent depolarization and presynaptic inhibition in pathways formed by both large and fine afferents are discussed. Emphasis is placed on the mechanisms underlying primary afferent depolarization, including the anatomical arrangement of the synapses involved, how depolarization can result in… Expand
8 THE ROLE OF DORSAL ROOT REFLEXES IN NEUROGENIC INFLAMMATION AND PAIN
Intradermal injection of capsaicin into the rat hindpaw causes flare and paw swelling. Both are dramatically reduced by sectioning the peripheral nerves that supply the distal hindlimb or by dorsalExpand
The Role of Dorsal Root Reflexes in Neurogenic Inflammation and Pain
Intradermal injection of capsaicin into the rat hindpaw causes flare and paw swelling. Both are dramatically reduced by sectioning the peripheral nerves that supply the distal hindlimb or by dorsalExpand
Adelta and C primary afferents convey dorsal root reflexes after intradermal injection of capsaicin in rats.
TLDR
The hypothesis that centrally mediated antidromic activity in Adelta and C primary afferent fibers contributes to the development of neurogenic inflammation, presumably by release of inflammatory substances in the periphery is supported. Expand
Contributions of dorsal root reflex and axonal reflex to formalin-induced inflammation
TLDR
It is concluded that ARs play a more important role than DRRs in formalin-induced neurogenic inflammation. Expand
Differential contribution of electrically evoked dorsal root reflexes to peripheral vasodilatation and plasma extravasation
TLDR
It is suggested that DRRs are involved in vasodilatation but not plasma extravasation in neurogenic inflammation in normal animals. Expand
Secondary hyperalgesia and presynaptic inhibition: an update
TLDR
Evidence gathered in support of a mechanistic model based on presynaptic interactions in the spinal dorsal horn between the terminals of low‐threshold mechanoreceptors and of nociceptors is reviewed and potential molecular mechanisms that may underlie this model and therefore be responsible for the development of secondary hyperalgesia are identified. Expand
CHAPTER 348 – Retrograde Signaling in the Nervous System: Dorsal Root Reflexes
TLDR
Experiments in which dorsal root reflexes are blocked by spinal cord administration of drugs that prevent GABAergic transmission interfere with the development of inflammation in the knee joint and in the skin, supporting the hypothesis that the retrogradely transmitted dorsal root Reflexes contribute to neurogenic inflammation. Expand
Heterosynaptic modulation of the dorsal root potential in the turtle spinal cord in vitro
TLDR
A subtle lateral excitatory interaction between primary afferents for the generation of PAD mediated by a non-spiking mechanism that may contribute to shaping of information transmitted by C and Aδ fibres in a spatially confined scale in analogy with the retina and olfactory bulb is suggested. Expand
Local and diffuse mechanisms of primary afferent depolarization and presynaptic inhibition in the rat spinal cord
  • M. Lidierth
  • Chemistry, Medicine
  • The Journal of physiology
  • 2006
Two types of dorsal root potential (DRP) were found in the spinal cord of urethane‐anaesthetized rats. Local DRPs with short latency‐to‐onset were evoked on roots close to the point of entry of anExpand
John Eccles’ studies of spinal cord presynaptic inhibition
  • W. Willis
  • Medicine, Chemistry
  • Progress in Neurobiology
  • 2006
TLDR
Presynaptic inhibition and primary afferent depolarization could be blocked by antagonists of GABA(A) receptors, implying a role of interneurons that release gamma aminobutyric acid in the inhibitory circuit. Expand
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TLDR
Though these events are reversible in the case of the acute inflammatory model, dorsal root reflexes as an initiator of persistent pain should be considered for chronic pain models where other more complex factors come into play, including secondary intracellular events and the sympathetic nervous system. Expand
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TLDR
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TLDR
Chronic arthritis was produced in rats by the injection of incomplete Freund's adjuvant into one knee joint and dorsal root reflexes could be recorded bilaterally from the proximal ends of the cut medial articular nerves (MANs) of the knee joint, indicating that these dorsal root Reflexes depended on activity in fine afferent fibers containing capsaicin receptors, presumably C fibers. Expand
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