Dorsal raphe neuronal activities are modulated by methylphenidate

@article{Tang2012DorsalRN,
  title={Dorsal raphe neuronal activities are modulated by methylphenidate},
  author={Bin Tang and Nachum Dafny},
  journal={Journal of Neural Transmission},
  year={2012},
  volume={120},
  pages={721-731}
}
This study investigated the electrophysiological properties of the dorsal raphe nucleus (DR) neurons in response to the acute and repetitive administration of methylphenidate (MPH). Activities of DR neurons were recorded from non-anesthetized, freely behaving rats previously implanted bilaterally with permanent semi microelectrodes. The main findings were: (1) after initial (acute) administration of MPH (2.5 mg/kg i.p.) on experimental day one (ED1), 56 % of DR units significantly changed their… CONTINUE READING

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