Dorsal premammillary nucleus differentially modulates defensive behaviors induced by different threat stimuli in rats

  title={Dorsal premammillary nucleus differentially modulates defensive behaviors induced by different threat stimuli in rats},
  author={D. Caroline Blanchard and Chun I Li and David T Hubbard and Chris M. Markham and Mu Yang and Lorey K. Takahashi and Robert J. Blanchard},
  journal={Neuroscience Letters},
Lesions of the dorsal premammillary nucleus (PMd) have been reported to produce dramatic reductions in responsivity of rats to a live cat. Such lesions provide a means of analyzing the potentially differential neural systems involved in different defensive behaviors, and the relationship between these systems and concepts such as anxiety. Rats with bilateral electrolytic lesions of the PMd were run in an elevated plus maze (EPM), exposed first to cat odor and then to a live cat, and assessed… Expand
Modulation of predatory odor processing following lesions to the dorsal premammillary nucleus
Findings confirm earlier findings of attenuation in defensiveness following electrolytic PMd lesions while extending these findings to suggest that the reduceddefensiveness occurs specifically in response to predatory odors. Expand
Lesions of structures showing FOS expression to cat presentation: Effects on responsivity to a Cat, Cat odor, and nonpredator threat
Results support the view that the dorsal premammillary nucleus is strongly and selectively involved in control of responsivity to predator stimuli. Expand
Blockade of NMDA or NO in the dorsal premammillary nucleus attenuates defensive behaviors
The results showed that both AP7 and NP significantly attenuated the behavioral responses induced by the live cat, suggesting that the NMDA/NO pathway plays an important role in the Behavioral responses mediated by the PMd. Expand
Effects of site-specific electrolytic and neurotoxic lesions on defensive responding in rodents
The use of predator-related stimuli, such as cat fur/skin odors, has proven to be useful in eliciting defensive responses in both wild and laboratory rodents. These behaviors, including freezing,Expand
Effects of lesions to the dorsal and ventral hippocampus on defensive behaviors in rats
A specific role for the ventral, not dorsal, hippocampus is suggested in modulating anxiety‐like behaviors in certain animal models of defense. Expand
Hypothalamic sites responding to predator threats – the role of the dorsal premammillary nucleus in unconditioned and conditioned antipredatory defensive behavior
The results support the view that hypothalamic processing of the actual and the contextual predatory threats share the same circuit, in which the dorsal premammillary nucleus (PMd) plays a pivotal role in amplifying this processing. Expand
Evidence for the thalamic targets of the medial hypothalamic defensive system mediating emotional memory to predatory threats
Investigation of the role of the dorsal premammillary nucleus's main thalamic targets in both unconditioned and conditioned defensive behaviors suggests that the PMd seems to be critically involved in the emotional memory processing related to predator cues. Expand
Differential Encoding of Predator Fear in the Ventromedial Hypothalamus and Periaqueductal Grey
Using single unit in vivo electrophysiological recordings in mice, neuronal populations in the medial hypothalamus and brainstem that encode defensive responses to a rat predator are identified and it is found that both structures encode both sensory as well as motor aspects of the behavior although with different kinetics. Expand
A study of the catecholaminergic inputs to the dorsal premammillary nucleus
Evidence suggests that the locus coeruleus is seemingly a part of the circuit responding to predatory threats, and, as shown by the present results, is the sole source of catecholaminergic inputs to the PMd, providing noradrenergic Inputs to the nucleus, which, by acting via beta adrenoceptor, seems to be critical for the expression of anti-predatory responses. Expand
Differential encoding of predator fear in the ventromedial hypothalamus and periaqueductal grey
Electrophysiological recordings of single units in behaving mice exposed to a rat are used to investigate the encoding of predator fear in the dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal grey, suggesting a distributed encoding of sensory and motor features in the medial hypothalamic-brainstem instinctive network. Expand


Severe Reduction of Rat Defensive Behavior to a Predator by Discrete Hypothalamic Chemical Lesions
The dorsal premammillary nucleus showed the most striking increase in Fos levels, and cell body-specific chemical lesions therein virtually eliminated two major components of defensive behavior but increased exploratory behavior, suggesting that this caudal hypothalamic nucleus plays a critical role in the expression of behavioral responses sometimes critical for survival of the individual. Expand
The medial hypothalamic defensive system: Hodological organization and functional implications
  • N. Canteras
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
  • 2002
The purpose of this review is to provide an overview of what is currently known about the functional and hodological organization of this hypothalamic circuit subserving defensive responses. Expand
‘When a rat smells a cat’: the distribution of Fos immunoreactivity in rat brain following exposure to a predatory odor
Robust Fos expression in the ventromedial hypothalamus, premamillary nucleus and periaqueductal gray confirms previous suggestions of a role for these areas in predator-induced defensive behavior and draws attention to this subregion as a possible interface between olfactory input and emotional output. Expand
Effect of anterior hypothalamic and mammillary area lesions on territorial aggressive behaviour in male rats
It is suggested that two distinct neural substrates exist in the medial hypothalamus, which normally modulate defensive or offensive aspects of intermale aggression in either the medial anterior hypothalamic area or the mammillary bodies. Expand
Combinatorial amygdalar inputs to hippocampal domains and hypothalamic behavior systems
The expression of innate reproductive, defensive, and ingestive behaviors appears to be controlled by three sets of medial hypothalamic nuclei, which are modulated by cognitive influences from theExpand
Fos immunoreactivity in the rat brain following consummatory elements of sexual behavior: a sex comparison
Differences between females and males were detected in the phases of sexual activity that resulted in Fos immunoreactivity in these brain areas, allowing more insight in the nature of the sensory and hormonal stimuli leading to the induction of Fos Immunoreactivity. Expand
Circadian modulation of Fos responses to odor of the red fox, a rodent predator, in the rat olfactory system
Results show that neuronal responses to an ethologically relevant odor follow a circadian rhythm similar to biologically neutral odors, suggesting that fox urine activates fear circuitry. Expand
Conditional and unconditional components of post-shock freezing
  • M. Fanselow
  • Medicine
  • The Pavlovian journal of biological science
  • 1980
Rats received shocks in one apparatus, and post-shock “freezing” was then assessed in that apparatus or in a different one, suggesting that post- shock freezing is entirely produced by conditioned fear elicited by cues associated with shock and that no part ofPost-shock freezing is an unconditional response (UR) directly eliciting by shock. Expand
The Rat Brain in Stereotaxic Coordinates, George Paxinos, Charles Watson (Eds.). Academic Press, San Diego, CA (1982), vii + 153, $35.00, ISBN: 0 125 47620 5
xi. A6.m. x. 160 10 Eiscn. J. S. and Marder. E. (1983) SOC. New+ sci. Ahsrr. 9. 75.l II Kushncr. P. D. and Barker. D. L. (1983) J. Nercrohiol. IJ. 17-28 12 Kushner P. D. and Mavnxd. E. A. (1977)Expand
Wiepkema, Effect of anterior hypothalamic and mammillary area lesions on territorial aggressive behaviour in male rats, Behav
  • Brain Res
  • 1983