Dorsal-mediated repression requires the formation of a multiprotein repression complex at the ventral silencer.

@article{Valentine1998DorsalmediatedRR,
  title={Dorsal-mediated repression requires the formation of a multiprotein repression complex at the ventral silencer.},
  author={Scott A. Valentine and Gong Chen and Tetyana Shandala and Juan David Uceda Fern{\'a}ndez and Sarah E. Mische and Robert E. Saint and Albert J. Courey},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 11},
  pages={6584-94}
}
Dorsal functions as both an activator and repressor of transcription to determine dorsoventral fate in the Drosophila melanogaster embryo. Repression by Dorsal requires the corepressor Groucho (Gro) and is mediated by silencers termed ventral repression regions (VRRs). A VRR in zerknüllt (zen) contains Dorsal binding sites as well as an essential element termed AT2. We have identified and purified an AT2 DNA binding activity in embryos and shown it to consist of cut (ct) and dead ringer (dri… CONTINUE READING

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