Dorsal hippocampal kindling produces a selective and enduring disruption of hippocampally mediated behavior.

@article{Hannesson2001DorsalHK,
  title={Dorsal hippocampal kindling produces a selective and enduring disruption of hippocampally mediated behavior.},
  author={Darren K Hannesson and John G Howland and Michael S. Pollock and Paul Mohapel and Amy E. Wallace and Michael E. Corcoran},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 12},
  pages={4443-50}
}
Kindling produces enduring neural changes that are subsequently manifest in enhanced susceptibility to seizure-evoking stimuli and alterations in some types of behavior. The present study investigated the effects of dorsal hippocampal (dHPC) kindling on a variety of behaviors to clarify the nature of previously reported effects on spatial task performance. Rats were kindled twice daily with dHPC stimulation until three fully generalized seizures were evoked. Beginning 7 d later and on… CONTINUE READING