Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm

  title={Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm},
  author={K. Liem and G. Tremml and H. Roelink and T. Jessell},
  • K. Liem, G. Tremml, +1 author T. Jessell
  • Published 1995
  • Biology, Medicine
  • Cell
  • The cellular interactions that control the differentiation of dorsal cell types from neural progenitors have been examined in neural plate explants. Certain genes that are expressed in the dorsal neural tube are initially expressed uniformly within the neural plate and appear to achieve their dorsal restriction through a Sonic hedgehog (SHH)-mediated repressive signal from the notochord. The acquisition of definitive dorsal cell fates, however, requires a contact-dependent signal from the… CONTINUE READING
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