Dorsal column myelopathy after intrathecal chemotherapy for leukemia

@article{Pinnix2017DorsalCM,
  title={Dorsal column myelopathy after intrathecal chemotherapy for leukemia},
  author={Chelsea C Pinnix and Linda Chi and Elias J Jabbour and Sarah A Milgrom and Grace Li Smith and Naval Daver and Naveen Garg and Matthew D. Cykowski and Greg N. Fuller and David Cachia and Carlos Kamiya-Matsuoka and Karin Woodman and Courtney D Dinardo and Nitin Jain and Tapan Mahendra Kadia and Naveen Pemmaraju and Maro Ohanian and Marina Y Konopleva and Hagop M Kantarjian and Bouthaina S Dabaja},
  journal={American Journal of Hematology},
  year={2017},
  volume={92},
  pages={155–160}
}
  • Chelsea C Pinnix, Linda Chi, +17 authors Bouthaina S Dabaja
  • Published in
    American journal of…
    2017
  • Medicine
  • American Journal of Hematology
  • Intrathecal chemotherapy with methotrexate, a folate antagonist, is widely used to treat central nervous system malignancies. The mechanisms underlying methotrexate-induced neurotoxicity are unclear but may be related to increased homocysteine levels. Intrathecal methotrexate-induced myelopathy mimicking subacute combined degeneration, with normal B12 levels, has been documented. We examined treatment and magnetic resonance imaging (MRI) characteristics of 13 patients with leukemia who received… CONTINUE READING
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