Dorsal Raphe Neurons Signal Reward through 5-HT and Glutamate

@article{Liu2014DorsalRN,
  title={Dorsal Raphe Neurons Signal Reward through 5-HT and Glutamate},
  author={Zhixiang Liu and J. Zhou and Y. Li and Fei Hu and Yao Lu and M. Ma and Qiru Feng and Ju-en Zhang and Daqing Wang and Jiawei Zeng and Junhong Bao and Ji-Young Kim and Zhou-feng Chen and S. Mestikawy and M. Luo},
  journal={Neuron},
  year={2014},
  volume={81},
  pages={1360-1374}
}
The dorsal raphe nucleus (DRN) in the midbrain is a key center for serotonin (5-hydroxytryptamine; 5-HT)-expressing neurons. Serotonergic neurons in the DRN have been theorized to encode punishment by opposing the reward signaling of dopamine neurons. Here, we show that DRN neurons encode reward, but not punishment, through 5-HT and glutamate. Optogenetic stimulation of DRN Pet-1 neurons reinforces mice to explore the stimulation-coupled spatial region, shifts sucrose preference, drives optical… Expand
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TLDR
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