Dorsal Forebrain-Specific Deficiency of Reelin-Dab1 Signal Causes Behavioral Abnormalities Related to Psychiatric Disorders

@article{Imai2017DorsalFD,
  title={Dorsal Forebrain-Specific Deficiency of Reelin-Dab1 Signal Causes Behavioral Abnormalities Related to Psychiatric Disorders},
  author={Hideaki Imai and Hirotaka Shoji and Masaki Ogata and Yoshiteru Kagawa and Yuji Owada and Tsuyoshi Miyakawa and Kenji Sakimura and Toshio Terashima and Yu Katsuyama},
  journal={Cerebral Cortex},
  year={2017},
  volume={27},
  pages={3485–3501}
}
Reelin-Dab1 signaling is involved in brain development and neuronal functions. The abnormalities in the signaling through either reduction of Reelin and Dab1 gene expressions or the genomic mutations in the brain have been reported to be associated with psychiatric disorders. However, it has not been clear if the deficiency in Reelin-Dab1 signaling is responsible for symptoms of the disorders. Here, to examine the function of Reelin-Dab1 signaling in the forebrain, we generated dorsal forebrain… CONTINUE READING
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