Dorothy Hodgkin and her contributions to biochemistry

@article{Howard2003DorothyHA,
  title={Dorothy Hodgkin and her contributions to biochemistry},
  author={Judith A. K. Howard},
  journal={Nature Reviews Molecular Cell Biology},
  year={2003},
  volume={4},
  pages={891-896}
}
  • J. Howard
  • Published 1 November 2003
  • Chemistry
  • Nature Reviews Molecular Cell Biology
The components of cells are molecules — non-living structures that are built up of atoms. It was Dorothy Hodgkin's life's work to determine the three-dimensional structures of many biologically important molecules using the relatively new technique of X-ray diffraction. For this pioneering work, she was awarded the Nobel Prize for Chemistry in 1964. 

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Dorothy Mary Crowfoot Hodgkin, O.M. 12 May 1910 – 29 July 1994

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  • Materials Science
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Dorothy Hodgkin was an X-ray crystallographer whose scientific career began in the 1930s and finished in the 1990s; her research had a deep influence on modern crystallography, chemistry and

Dorothy Hodgkin: A Life

Dorothy Hodgkin (1910-1994) was renowned for her medically-important work on penicillin, vitamin B12 and insulin. Fully engaged with the political and social currents of her time, she participated in

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THE importance of water of crystallization in maintaining the regular structure of protein crystals has already been shown in the X-ray examination of wet and dry crystals of three different

Structure of Calciferol

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The paper describes the arrangement of the atoms within rhombohedral crystals of 2Zn pig insulin as seen in electron density maps calculated from X-ray data extending to 1.5 A at room temperature and refined to R = 0.153, finding all but eight of the active atoms in the protein form at least one hydrogen bond.

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TLDR
Very recently the authors have acquired a great wealth of new information about the actual arrangement in space of the atoms in insulin molecules in crystals, which can begin to answer many of the questions chemists and biochemists have been asking about the behaviour of insulin for years past.

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The name corrin was adopted during the first international symposium on vitamin B12 at Hamburg in 1957 as the name of the nucleus shown in I and considered to be present as a cobalt complex in

Structure of Rhombohedral 2 Zinc Insulin Crystals

An electron density map has been calculated at a resolution of 2.8 Å which shows many details of the arrangement of the atoms in rhombohedral crystals of insulin.