Dormant cancer cells retrieved from metastasis-free organs regain tumorigenic and metastatic potency.

@article{Suzuki2006DormantCC,
  title={Dormant cancer cells retrieved from metastasis-free organs regain tumorigenic and metastatic potency.},
  author={Mika Suzuki and Evangeline Sari Mose and Val{\'e}rie Montel and David Tarin},
  journal={The American journal of pathology},
  year={2006},
  volume={169 2},
  pages={673-81}
}
This study shows that solitary, dormant human cancer cells, retrieved from metastasis-free organs of animals carrying spontaneously metastatic primary tumors, can reactivate their tumorigenic and metastatic potency. The tumors were produced by MDA-MB-435 CL16 breast cancer cells permanently labeled with green fluorescent protein and the neomycin resistance gene. This enabled unequivocal identification of tumor cells emerging from organ explants cultured in neomycin to eliminate nonneoplastic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

Similar Papers

Loading similar papers…