Dormancy of inhibitory interneurons in a model of temporal lobe epilepsy.

  title={Dormancy of inhibitory interneurons in a model of temporal lobe epilepsy.},
  author={J W Bekenstein and E W Lothman},
  volume={259 5091},
In humans temporal lobe epilepsy (TLE) is characterized by recurrent seizures, neuronal hyperexcitability, and selective loss of certain neuronal populations in the hippocampus. Animal models of the condition indicate that a diminution of inhibition mediated by gamma-aminobutyric acid (GABA) accounts for the altered function, and it has been hypothesized that the diminution arises because GABAergic basket interneurons are "dormant" as a result of their being disconnected from excitatory inputs… CONTINUE READING


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