Dormancy of inhibitory interneurons in a model of temporal lobe epilepsy.

@article{Bekenstein1993DormancyOI,
  title={Dormancy of inhibitory interneurons in a model of temporal lobe epilepsy.},
  author={J W Bekenstein and E W Lothman},
  journal={Science},
  year={1993},
  volume={259 5091},
  pages={97-100}
}
In humans temporal lobe epilepsy (TLE) is characterized by recurrent seizures, neuronal hyperexcitability, and selective loss of certain neuronal populations in the hippocampus. Animal models of the condition indicate that a diminution of inhibition mediated by gamma-aminobutyric acid (GABA) accounts for the altered function, and it has been hypothesized that the diminution arises because GABAergic basket interneurons are "dormant" as a result of their being disconnected from excitatory inputs… CONTINUE READING

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