Dormancy is not necessary or sufficient for bacterial persistence.

  title={Dormancy is not necessary or sufficient for bacterial persistence.},
  author={Mehmet A. Orman and Mark P. Brynildsen},
  journal={Antimicrobial agents and chemotherapy},
  volume={57 7},
The antibiotic tolerances of bacterial persisters have been attributed to transient dormancy. While persisters have been observed to be growth inhibited prior to antibiotic exposure, we sought to determine whether such a trait was essential to the phenotype. Furthermore, we sought to provide direct experimental evidence of the persister metabolic state so as to determine whether the common assumption of metabolic inactivity was valid. Using fluorescence-activated cell sorting (FACS), a… CONTINUE READING