Dormancy in a model of murine B cell lymphoma.

Abstract

A B cell lymphoma model of dormancy in mice was established by prior immunization to the B cell membrane immunoglobulin idiotype. The antibody to the idiotype was the major factor in inducing and maintaining dormancy and acted primarily as an agonist rather than via effector functions. CD8+ T cells synergized with anti-Id in inducing dormancy by secreting IFN-gamma. Cycling in the dormant population was reduced 3-5 fold, but each mouse contained approximately 10(6) tumor cells in its spleen, some of which were cycling, during the 1.5 years of observation. Thus, replication is balanced by cell death.

Cite this paper

@article{Uhr2001DormancyIA, title={Dormancy in a model of murine B cell lymphoma.}, author={Jonathan W . Uhr and Radu Marches}, journal={Seminars in cancer biology}, year={2001}, volume={11 4}, pages={277-83} }