Dormancy Phenotype Displayed by Extracellular Mycobacterium tuberculosis within Artificial Granulomas in Mice

@article{Karakousis2004DormancyPD,
  title={Dormancy Phenotype Displayed by Extracellular Mycobacterium tuberculosis within Artificial Granulomas in Mice},
  author={Petros C Karakousis and Tetsuyuki Yoshimatsu and Gyanu Lamichhane and Samuel C. Woolwine and Eric Nuermberger and Jacques H. Grosset and William R Bishai},
  journal={The Journal of Experimental Medicine},
  year={2004},
  volume={200},
  pages={647 - 657}
}
Mycobacterium tuberculosis residing within pulmonary granulomas and cavities represents an important reservoir of persistent organisms during human latent tuberculosis infection. We present a novel in vivo model of tuberculosis involving the encapsulation of bacilli in semidiffusible hollow fibers that are implanted subcutaneously into mice. Granulomatous lesions develop around these hollow fibers, and in this microenvironment, the organisms demonstrate an altered physiologic state… CONTINUE READING