Doping-control analysis of the 5alpha-reductase inhibitor finasteride: determination of its influence on urinary steroid profiles and detection of its major urinary metabolite.

@article{Thevis2007DopingcontrolAO,
  title={Doping-control analysis of the 5alpha-reductase inhibitor finasteride: determination of its influence on urinary steroid profiles and detection of its major urinary metabolite.},
  author={Mario Thevis and Hans Geyer and Ute Mareck and Ulrich Flenker and Wilhelm Schaenzer},
  journal={Therapeutic drug monitoring},
  year={2007},
  volume={29 2},
  pages={236-47}
}
5alpha-Reductase inhibitors such as finasteride are prohibited in sports according to the World Anti-Doping Agency. This class of drugs is used therapeutically to treat benign prostatic hyperplasia, as well as male baldness, by decreasing 5alpha-reductase activity. Accordingly, metabolic pathways of endogenous as well as synthetic steroids are influenced, which complicates the evaluation of steroid profiles in sports drug testing. The possibility of manipulating steroid excretion profiles and… CONTINUE READING