Dopaminochrome induces caspase-independent apoptosis in the mesencephalic cell line, MN9D.

Abstract

Parkinson's disease is characterized by a deficiency in motor cortex modulation due to degeneration of pigmented dopaminergic neurons of the substantia nigra projecting to the striatum. These neurons are particularly susceptible to oxidative stress, perhaps because of their dopaminergic nature. Like all catecholamines, dopamine is easily oxidized, first to… (More)
DOI: 10.1111/j.1471-4159.2012.07756.x

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Cite this paper

@article{Linsenbardt2012DopaminochromeIC, title={Dopaminochrome induces caspase-independent apoptosis in the mesencephalic cell line, MN9D.}, author={Andrew J Linsenbardt and Julie M Breckenridge and Gerald H. Wilken and Heather Macarthur}, journal={Journal of neurochemistry}, year={2012}, volume={122 1}, pages={175-84} }