Corpus ID: 45578736

Dopaminergic regulation of striatal acetylcholine release: importance of D1 and N-methyl-D-aspartate receptors.

@article{Damsma1991DopaminergicRO,
  title={Dopaminergic regulation of striatal acetylcholine release: importance of D1 and N-methyl-D-aspartate receptors.},
  author={G. Damsma and G. Robertson and C. Tham and H. Fibiger},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1991},
  volume={259 3},
  pages={
          1064-72
        }
}
  • G. Damsma, G. Robertson, +1 author H. Fibiger
  • Published 1991
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • The dopaminergic regulation of striatal cholinergic activity was studied using in vivo microdialysis to measure interstitial concentrations of acetylcholine (ACh) and choline in the striata of freely moving rats. The quaternary acetylcholinesterase inhibitor neostigmine (100 nM) was included in the perfusion solution to increase the recovery of ACh. d-Amphetamine (2 mg/kg, s.c.) and nomifensine (5 mg/kg, s.c.) increased the concentration of ACh in the striatal dialysate by 40 to 60… CONTINUE READING
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