Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.

@article{Massie2011DopaminergicNO,
  title={Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.},
  author={Ann Massie and Anneleen Schallier and Seong Woong Kim and Ruani N. Fernando and Sho Kobayashi and Heike Beck and Dimitri de Bundel and Katia Vermoesen and Shiro Bannai and Ilse J. Smolders and Marcus Conrad and Nikolaus Plesnila and Hideyo Sato and Yvette Michotte},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2011},
  volume={25 4},
  pages={
          1359-69
        }
}
Malfunctioning of system x(c)(-), responsible for exchanging intracellular glutamate for extracellular cystine, can cause oxidative stress and excitotoxicity, both important phenomena in the pathogenesis of Parkinson's disease (PD). We used mice lacking xCT (xCT(-/-) mice), the specific subunit of system x(c)(-), to investigate the involvement of this antiporter in PD. Although cystine that is imported via system x(c)(-) is reduced to cysteine, the rate-limiting substrate in the synthesis of… CONTINUE READING

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