Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model.

@article{Takagi2005DopaminergicNG,
  title={Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model.},
  author={Yasushi Takagi and Jun Takahashi and Hidemoto Saiki and Asuka Morizane and Takuya Hayashi and Yo Kishi and Hitoshi Fukuda and Yo Okamoto and Masaomi Koyanagi and Makoto Ideguchi and Hideki Hayashi and Takayuki Imazato and Hiroshi Kawasaki and Hirofumi Suemori and Shigeki Omachi and Hidehiko Iida and Nobuyuki Itoh and Norio Nakatsuji and Yoshiki Sasai and N. Hashimoto},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 1},
  pages={102-9}
}
Parkinson disease (PD) is a neurodegenerative disorder characterized by loss of midbrain dopaminergic (DA) neurons. ES cells are currently the most promising donor cell source for cell-replacement therapy in PD. We previously described a strong neuralizing activity present on the surface of stromal cells, named stromal cell-derived inducing activity (SDIA). In this study, we generated neurospheres composed of neural progenitors from monkey ES cells, which are capable of producing large numbers… CONTINUE READING
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