Dopaminergic network differences in human impulsivity.

@article{Buckholtz2010DopaminergicND,
  title={Dopaminergic network differences in human impulsivity.},
  author={Joshua W. Buckholtz and Michael Tilghman Treadway and Ronald L. Cowan and Neil D. Woodward and Rui Li and M. Sib Ansari and Ronald M. Baldwin and Ashley N. Schwartzman and Evan S. Shelby and Clarence E. Smith and Robert M. Kessler and David H. Zald},
  journal={Science},
  year={2010},
  volume={329 5991},
  pages={
          532
        }
}
Dopamine (DA) has long been implicated in impulsivity, but the precise mechanisms linking human variability in DA signaling to differences in impulsive traits remain largely unknown. By using a dual-scan positron emission tomography approach in healthy human volunteers with amphetamine and the D2/D3 ligand [18F]fallypride, we found that higher levels of trait impulsivity were predicted by diminished midbrain D2/D3 autoreceptor binding and greater amphetamine-induced DA release in the striatum… CONTINUE READING

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