Dopaminergic mechanisms involved in prolactin release after mifepristone and naloxone treatment during late pregnancy in the rat.

@article{Soaje2006DopaminergicMI,
  title={Dopaminergic mechanisms involved in prolactin release after mifepristone and naloxone treatment during late pregnancy in the rat.},
  author={Marta Soaje and Susana Ruth Valdez and Claudia Bregonzio and Alicia Beatriz Penissi and Ricardo P. Deis},
  journal={Neuroendocrinology},
  year={2006},
  volume={84 1},
  pages={58-67}
}
BACKGROUND/AIMS During late pregnancy, the antiprogesterone mifepristone facilitates prolactin release. This effect is enhanced by administration of the opioid antagonist naloxone, suggesting an inhibitory-neuromodulatory role of the opioid system. Since hypothalamic dopamine (DA) is the main regulator of prolactin release, in this study we explored the role of DA on prolactin release induced by mifepristone and naloxone treatment. METHODS/RESULTS Rats on day 19 of pregnancy were used… CONTINUE READING

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