Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of α-synuclein.

@article{Schlachetzki2016DopaminergicLI,
  title={Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of α-synuclein.},
  author={Johannes C M Schlachetzki and Thomas W. Grimm and Zinayida Schlachetzki and Nada M. B. Ben Abdallah and Benjamin Ettle and Patrizia Voehringer and Boris Ferger and Beate Winner and Silke Nuber and J{\"u}rgen Winkler},
  journal={Journal of neuroscience research},
  year={2016},
  volume={94 1},
  pages={62-73}
}
Nonmotor symptoms of cognitive and affective nature are present in premotor and motor stages of Parkinson's disease (PD). Neurogenesis, the generation of new neurons, persists throughout the mammalian life span in the hippocampal dentate gyrus. Adult hippocampal neurogenesis may be severely affected in the course of PD, accounting for some of the neuropsychiatric symptoms such as depression and cognitive impairment. Two important PD-related pathogenic factors have separately been attributed to… CONTINUE READING