Dopaminergic involvement in effort-based but not impulsive reward processing in smokers.

@article{Freeman2013DopaminergicII,
  title={Dopaminergic involvement in effort-based but not impulsive reward processing in smokers.},
  author={Tom P Freeman and Celia J. A. Morgan and Brigitta Brandner and Basil Almahdi and H. Valerie Curran},
  journal={Drug and alcohol dependence},
  year={2013},
  volume={130 1-3},
  pages={109-14}
}
BACKGROUND A reduction in reward responsivity and an increase in temporal discounting of rewards are both evident in smokers during acute abstinence compared to satiation. However, it is not yet known whether these processes can be modulated pharmacologically in smokers, other than with nicotine or tobacco. METHODS A double-blind placebo controlled crossover design assessed the effects of 0.5 mg pramipexole, a dopamine D₂/D₃ agonist, in smokers following 2 h of abstinence. Reward responsivity… CONTINUE READING