Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity.

@article{Glaser2003DopaminergicIO,
  title={Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity.},
  author={Shannon S. Glaser and Domenico Alvaro and Tania A Roskams and Jo Lynne Phinizy and George Stoica and Heather Francis and Yoshiyuki Ueno and Barbara Barbaro and Marco Marzioni and Jeremy Mauldin and Sobia Rashid and Maria Grazia Mancino and Gene D Lesage and Gianfranco D Alpini},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2003},
  volume={284 4},
  pages={G683-94}
}
To determine the role and mechanisms of action by which dopaminergic innervation modulates ductal secretion in bile duct-ligated rats, we determined the expression of D1, D2, and D3 dopaminergic receptors in cholangiocytes. We evaluated whether D1, D2 (quinelorane), or D3 dopaminergic receptor agonists influence basal and secretin-stimulated choleresis and lumen expansion in intrahepatic bile duct units (IBDU) and cAMP levels in cholangiocytes in the absence or presence of BAPTA-AM… CONTINUE READING

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Stimulation of alpha2-adrenergic receptor inhibits G693 DOPAMINERGIC REGULATION OF CHOLANGIOCYTE SECRETION AJP-Gastrointest Liver Physiol

N Kanno, G LeSage, +3 authors G. Alpini
APRIL • 2003
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