Dopaminergic functional supersensitivity: effects of chronic L-dopa and carbidopa treatment in an animal model of Parkinson's disease.

@article{Hossain1993DopaminergicFS,
  title={Dopaminergic functional supersensitivity: effects of chronic L-dopa and carbidopa treatment in an animal model of Parkinson's disease.},
  author={Mohammed Anwar Hossain and Norman Weiner},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={267 3},
  pages={1105-11}
}
We have evaluated the effects of L-Dopa and carbidopa treatment (30 days) on dopamine (DA) turnover, intracellular cyclic AMP (cAMP) accumulation and tetrahydrobiopterin levels in the nigrostriatal pathway of rats with a unilateral 6-OHDA lesions (greater than 90% lesions). We observed significant increase in the 3,4-dihydroxy-phenylacetic acid/DA and homovanillic acid/DA ratios, and in basal cAMP levels (92%) in the ipsilateral striatum, but not in the substantia nigra when compared to the… CONTINUE READING
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