Dopaminergic function and progression of Parkinson's disease: PET findings.

Abstract

Recent PET studies in Parkinson's disease (PD) have shown that the progression of neurodegeneration follows an exponential decay pattern. Most of the damage to the nigrostriatal dopamine system occurs during the presymptomatic phase of the disease and the first few years following symptom onset. The progressive loss of dopaminergic neurons is accompanied by… (More)
DOI: 10.1016/S1353-8020(09)70833-8

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