Dopaminergic effects of non-hydroxylated rigid analogs of apomorphine.

  title={Dopaminergic effects of non-hydroxylated rigid analogs of apomorphine.},
  author={D B Rusterholz and John Paul Long and Jan R. Flynn and Joseph G. Cannon and T Lee and J P Pease and James A. Clemens and David T. Wong and Frank P. Bymaster},
  journal={European journal of pharmacology},
  volume={55 1},
A series of rigid analogs of apomorphine lacking aromatic hydroxyl substitutents were evaluated for dopaminergic properties. Three compounds, N-methyl-N-propyl-2-aminotetralin (Me-Pr-2-AT), N-N-dipropyl-2-aminotetralin (Di-pr-2-AT) and N,N-dipropyl-2-aminoindane (Di-Pr-2-AI) induced emesis in dogs, contralateral circling in unilaterally lesioned rats, and inhibited prolactin secretion. The induced circling responses, however, were attenuated by prior treatment with alpha-methyl-p-tyrosine… CONTINUE READING