Dopaminergic dysfunction in abstinent dexamphetamine users: results from a pharmacological fMRI study using a reward anticipation task and a methylphenidate challenge.

@article{Schouw2013DopaminergicDI,
  title={Dopaminergic dysfunction in abstinent dexamphetamine users: results from a pharmacological fMRI study using a reward anticipation task and a methylphenidate challenge.},
  author={Marieke LJ Schouw and Michiel B. de Ruiter and Anne Marije Kaag and Wim van den Brink and Ram{\'o}n J L Lindauer and L. Reneman},
  journal={Drug and alcohol dependence},
  year={2013},
  volume={130 1-3},
  pages={
          52-60
        }
}
BACKGROUND Dopamine (DA) is involved in systems governing motor actions, motivational processes and cognitive functions. Preclinical studies have shown that even relatively low doses of d-amphetamine (dAMPH) (equivalent to doses used in clinical Practice) can lead to DA neurotoxicity in rodents and non-human primates (Ricaurte et al., 2005). METHODS Therefore, we investigated the DAergic function in eight male recreational users of dAMPH and eight male healthy controls using functional… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 61 references

Do individuals with former amphetamine dependence have cognitive deficits?

Nordic journal of psychiatry • 2005
View 4 Excerpts
Highly Influenced

Addiction: beyond dopamine reward circuitry.

Proceedings of the National Academy of Sciences of the United States of America • 2011